Biochemistry

The Chronotherapeutic Index: Integrating Circadian, Metabolic, and Tumor Clock Parameters in Chemotherapy Timing

Authors: Stephan Brown
Comments: 15 Pages. Licensed under CC-BY 4.0 (Note by ai.viXra.org Admin: Please cite listed scientific references)

Meta-analysis of 11,842 patients across 63 studies proposes a Chronotherapeutic Index integrating host CYP3A4 rhythms, tumor clock gene disruption, and metabolic factors. Optimized timing was associated with 41% lower severe toxicity and 34% higher response rates. A proposed framework for personalizing chemotherapy administration using routine clinical data.
Category: Biochemistry