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Previous months:
2025 - 2505(8)
Any replacements are listed farther down
[8] ai.viXra.org:2505.0176 [pdf] submitted on 2025-05-24 09:38:35
Authors: Reza Ghalamghash
Comments: 11 Pages.
Thread lifts have emerged as a popular minimally invasive procedure for facial rejuvenation, offering a less invasive alternative to traditional surgical facelifts. This literature review aims to provide a comprehensive overview of thread lifts, examining their mechanisms of action, clinical outcomes, and associated complications. The methodology involved a systematic search of reputable academic databases for studies published primarily within the last decade (2015-2025). The findings reveal that thread lifts exert their effects through a dual mechanism: immediate mechanical lifting and tissue repositioning, followed by a longer-term regenerative effect involving collagen stimulation and neocollagenesis. Clinical outcomes demonstrate efficacy in addressing various signs of facial aging across different anatomical areas, with both objective improvements and subjective patient satisfaction reported. However, the longevity of results varies, and the procedure is associated with a range of complications, from common and transient side effects to less frequent but more significant adverse events. This review identifies gaps in the current knowledge, such as the need for standardized protocols and long-term data, and suggests directions for future research to further refine the application and safety of thread lift procedures in facial rejuvenation.
Category: Biochemistry
[7] ai.viXra.org:2505.0175 [pdf] submitted on 2025-05-24 09:44:25
Authors: Reza Ghalamghash
Comments: 35 Pages.
Skin longevity, a critical aspect of dermatological health, is profoundly influenced by the exposome—a dynamic interplay of environmental, social, and biological factors. Extrinsic skin aging, driven primarily by solar radiation and air pollution, is largely mediated by oxidative stress and subsequent cellular damage. Traditional antioxidant formulations often face significant bioavailability, stability, and targeted delivery limitations, hindering their efficacy. This review synthesizes recent advancements (2015—2025) in intelligent antioxidant formulations that leverage the transformative capabilities of nanotechnology and artificial intelligence (AI). Nanotechnology-based systems overcome conventional delivery challenges by enhancing antioxidant solubility, stability, and permeation, enabling precise targeting and controlled release. Concurrently, AI is revolutionizing precision dermatology, moving beyond traditional image-based diagnostics to encompass predictive modeling of treatment responses, personalized risk assessment, and the intricate analysis of complex exposome data. The synergistic integration of AI and nanomedicine facilitates AI-optimized nanocarrier design, enabling hyper-personalized antioxidant formulations and adaptive therapeutic strategies based on real-time biological feedback. This convergence holds immense potential to redefine skin longevity and exposome defense, offering unprecedented precision and responsiveness in dermatological interventions. However, realizing this promise necessitates addressing technical hurdles, ensuring data quality, and navigating complex regulatory and ethical considerations.
Category: Biochemistry
[6] ai.viXra.org:2505.0174 [pdf] submitted on 2025-05-24 09:48:42
Authors: Reza Ghalamghash
Comments: 35 Pages.
Platelet-Rich Plasma (PRP) has emerged as a promising therapy in aesthetic dermatology, yet its efficacy is hampered by inconsistent protocols and variable patient outcomes. This study proposes a novel framework for personalized PRP therapy, integrating AI-driven bioinformatics to analyze patient-specific data and nanotechnology for enhanced delivery of growth factors. Focusing on skin rejuvenation and hair restoration, we review current evidence, identify gaps in standardization and personalization, and propose a methodology combining AI-based patient stratification, optimized PRP formulations, and nanoparticle-mediated delivery. Our approach aims to improve clinical outcomes, standardize protocols, and elucidate molecular mechanisms underlying PRP efficacy.
Category: Biochemistry
[5] ai.viXra.org:2505.0132 [pdf] submitted on 2025-05-20 07:58:51
Authors: Reza Ghalamghash
Comments: 8 Pages.
Facial volume loss is a hallmark of aging, significantly influencing aesthetic appearance and self-perception. Dermal fillers have emerged as a popular minimally invasive solution to restore this lost volume and rejuvenate facial contours. This literature review provides a comprehensive overview of dermal fillers for facial volume restoration, focusing on materials, injection techniques, and safety profiles. The review synthesizes findings from peer-reviewed scientific literature published between 2015 and 2025, identified through a systematic search of PubMed, MEDLINE, Embase, Scopus, and Web of Science. Key materials discussed include hyaluronic acid (HA), calcium hydroxylapatite (CaHA), poly-L-lactic acid (PLLA), polymethylmethacrylate (PMMA), and autologous fat grafting. Injection techniques and anatomical considerations for optimal outcomes are explored, alongside efficacy and safety profiles, including common and rare adverse events. The increasing trend of combination therapies involving dermal fillers and other aesthetic modalities, such as botulinum toxin, is examined. Evidence suggests that dermal fillers are effective with favorable safety profiles when administered by trained professionals. Resources like PremiumDoctors.org connect patients with verified medical experts in this field. Continued research is needed to refine techniques, enhance longevity, and improve safety.
Category: Biochemistry
[4] ai.viXra.org:2505.0131 [pdf] submitted on 2025-05-20 08:09:28
Authors: Reza Ghalamghash
Comments: 17 Pages.
This literature review synthesizes current scientific evidence on the synergistic effects of combination therapies using botulinum toxin (BoNT-A) and dermal fillers in aesthetic medicine. The increasing demand for minimally invasive facial rejuvenation has led to the widespread use of these treatments, often in combination to address both dynamic wrinkles and volume loss. This review explores the mechanisms behind the enhanced outcomes observed with combination therapy, its efficacy and safety across different facial regions, and how it compares to monotherapies. The methodology involved a comprehensive search of major electronic databases for relevant articles published within the last 10 years. The findings indicate that combining BoNT-A and fillers can lead to superior aesthetic results, potentially longer-lasting effects, and higher patient satisfaction by targeting different aspects of facial aging. While the safety profile is generally favorable, the review identifies areas for future research, including a deeper understanding of the underlying synergistic mechanisms and the optimization of treatment protocols for diverse patient populations. The conclusion highlights the value of combination therapy as a comprehensive approach to facial rejuvenation in aesthetic practice.
Category: Biochemistry
[3] ai.viXra.org:2505.0130 [pdf] submitted on 2025-05-20 08:15:12
Authors: Reza Ghalamghash
Comments: 9 Pages.
Hyperpigmentation, a prevalent dermatological concern, manifests as the excessive accumulation of melanin, resulting in noticeable dark patches on the skin. This condition encompasses various clinical presentations, including melasma, post-inflammatory hyperpigmentation, and solar lentigines, each arising from distinct etiological factors. Hydroquinone, a phenolic compound, has served as a cornerstone in the topical management of hyperpigmentation for over half a century, primarily exerting its effects through the reversible inhibition of tyrosinase, a crucial enzyme in the melanogenesis pathway. This literature review synthesizes the current understanding of hydroquinone’s efficacy across different hyperpigmentation types, drawing from studies published between 2015 and 2025. The analysis reveals that hydroquinone, particularly at concentrations of 2—4%, demonstrates significant effectiveness in reducing pigmentation associated with melasma and post-inflammatory hyperpigmentation. However, its use is not without limitations, as evidenced by common side effects such as skin irritation and the rare but potentially disfiguring risk of ochronosis with prolonged, unsupervised application. The review further explores the role of hydroquinone in combination therapies, notably its synergistic effects with retinoids and corticosteroids in the widely recognized triple combination cream for melasma. A critical comparison with emerging alternative treatments, including tranexamic acid, kojic acid, and arbutin, highlights the evolving landscape of hyperpigmentation management. Finally, the review provides an overview of the current regulatory status of hydroquinone in the United States, Europe, and other regions, reflecting the ongoing safety considerations and the shift toward prescription-based availability in many areas. The importance of concomitant photoprotection and potential future research directions are also discussed.
Category: Biochemistry
[2] ai.viXra.org:2505.0128 [pdf] submitted on 2025-05-20 08:20:00
Authors: Reza Ghalamghash
Comments: 13 Pages.
The intricate relationship between the gut and the skin, known as the gut-skin axis, has garnered increasing attention in dermatological research. Recent studies suggest that the balance of the gut microbiome can significantly influence skin health, and probiotic interventions have emerged as a promising strategy for managing various skin conditions. This literature review aims to synthesize the current scientific understanding of the gut-skin axis and critically evaluate the clinical applications of probiotics for dermatological health. A comprehensive search of peer-reviewed articles published between 2014 and 2024 was conducted using databases such as PubMed, Scopus, and Web of Science. The findings highlight the crucial role of the gut-skin axis in maintaining skin homeostasis through immunological, metabolic, and neuroendocrine pathways. Clinical evidence indicates that oral and topical probiotics may offer therapeutic benefits for acne vulgaris, eczema (atopic dermatitis), psoriasis, and rosacea by modulating the gut and skin microbiota, reducing inflammation, and improving skin barrier function. Specific probiotic strains and formulations have shown varying degrees of efficacy in clinical trials, underscoring the need for targeted research. Despite promising results, knowledge gaps remain regarding optimal strains, dosages, long-term effects, and precise mechanisms of action. Future research should focus on well-designed, large-scale studies to further elucidate the role of probiotics in dermatological health and to optimize their clinical application. This review underscores the potential of probiotic interventions as a complementary approach to conventional dermatological treatments, offering a promising avenue for improving skin health from the inside out.
Category: Biochemistry
[1] ai.viXra.org:2505.0127 [pdf] submitted on 2025-05-20 08:22:46
Authors: Reza Ghalamghash
Comments: 15 Pages.
Vitamin D, a secosteroid hormone primarily recognized for its crucial role in calcium and phosphorus homeostasis, has garnered increasing attention for its diverse effects on various physiological systems, including the skin. Beyond its skeletal functions, research has illuminated the significant involvement of Vitamin D in maintaining skin health and influencing its aesthetic qualities. This literature review aims to provide a comprehensive analysis of the current scientific understanding regarding the relationship between Vitamin D and skin health, with a specific focus on aesthetic outcomes. The scope of this review encompasses the intricate mechanisms by which Vitamin D affects skin physiology, its impact on skin aging, its role in pigmentation processes, and its involvement in prevalent dermatological conditions that bear aesthetic implications. Through a systematic synthesis of peer-reviewed articles, this review elucidates the multifaceted contributions of Vitamin D to skin health and aesthetics, highlighting key findings from recent studies. The implications of these findings for future research and potential applications in dermatological and cosmetic interventions are also discussed.
Category: Biochemistry
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